Công bố khoa học

A mini review on carrier development for delivery of anti-cancer oligonucleotide

Le Thanh Do * , Pham Thi Thuy Linh, Nguyen Thi Ha “A mini review on carrier development for delivery of anti-cancer oligonucleotide” DTU Journal of Science & Technology (in English). (2019) 4(35): 28-35.

Abstract

Research on oligonucleotide-based drug (OND) development in the last three decades has achieved certain success, with some drugs licensed by the US Food and Drug Administration (FDA). Although research on developing anti-cancer ONDs has not yet resulted in any commercial drug, it has revealed many potential anti-cancer sequences. The results prompted scientists to look for new potential sequences and develop different delivery forms and carriers. In this study, we briefly review approaches in essential steps of anti-cancer OND development. Studies on miR-34a, one of the most interesting oligonucleotide (ON) types and spherical form of ONs, that showed distinct and good properties, are presented in more detail.

 

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